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Related Experiment Videos

Pathological difference between retractile and cryptorchid testes.

S W Han1, T Lee, J H Kim

  • 1Department of Urology, Yonsei University College of Medicine, Seoul, Korea.

The Journal of Urology
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

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Histological analysis revealed significant differences in germ and Sertoli cells between retractile and cryptorchid testes. However, similar tubular degeneration suggests retractile testes may require treatment.

Area of Science:

  • Pediatric Urology
  • Reproductive Medicine
  • Histopathology

Background:

  • Retractile testes are often considered benign, but their long-term histological impact is not fully understood.
  • Cryptorchidism, or undescended testes, is known to cause testicular damage.
  • Comparing these conditions can elucidate the effects of testicular position on histology.

Purpose of the Study:

  • To compare testicular biopsies from retractile and cryptorchid testes.
  • To determine the histological effect of testicular retraction.
  • To assess the necessity of treatment for retractile testes.

Main Methods:

  • 61 testicular biopsies from boys with retractile testes (age 1.3-9.8 years) and 115 from boys with cryptorchidism (age 0.5-14.9 years) were analyzed.

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  • Histological parameters for germ cells (S/T value) and Sertoli cells were determined.
  • Tubular degeneration (phases V-VII) was assessed and compared between groups.

    • Main Results:

    • Retractile testes showed significantly higher mean average spermatogonial number (S/T value) (2.96±1.33) compared to cryptorchid testes (0.61±0.87).
    • Sertoli cell index was also higher in retractile testes (26.81±6.75) versus cryptorchid testes (23.04±5.85).
    • No statistically significant difference was found in the tubular degeneration phase V to VII ratio between retractile (0.23±0.18) and cryptorchid testes (0.22±0.17).

    Conclusions:

    • The similar degree of tubular degeneration suggests that retractile testes undergo histological changes comparable to cryptorchid testes.
    • These findings indicate that retractile testes may not be entirely benign.
    • Hormonal or surgical therapy may be necessary for retractile testes that do not descend spontaneously.