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Related Experiment Videos

Tyr-W-MIF-1-induced conditioned place preference.

W L Nores1, R D Olson, G A Olson

  • 1Department of Psychology, University of New Orleans, LA 70148, USA. wnores@nba19.med.uth.tmc.edu

Peptides
|August 24, 1999
PubMed
Summary

Tyr-W-MIF-1 demonstrated opiate agonistic effects in rats during conditioned place preference tests at high doses. However, lower doses of Tyr-W-MIF-1 did not show any opiate antagonistic properties.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Tyr-Pro-Trp-Gly NH2 (Tyr-W-MIF-1) exhibits dose-dependent mu-opiate agonistic/antagonistic effects.
  • The conditioned place preference (CPP) test is a standard behavioral paradigm for assessing drug-induced reward and aversion.

Purpose of the Study:

  • To investigate the opiate agonistic and antagonistic properties of Tyr-W-MIF-1 using the CPP test.
  • To determine if Tyr-W-MIF-1 produces conditioned place preference or affects morphine-induced CPP.

Main Methods:

  • Rats received alternating intracerebroventricular (ICV) injections of saline and Tyr-W-MIF-1 (0 or 200 microg) to assess agonistic effects.
  • Morphine-induced CPP was challenged with varying doses of Tyr-W-MIF-1 (0, 25, 50, or 100 microg) to evaluate antagonistic properties.

Main Results:

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  • Tyr-W-MIF-1 administration (200 microg) resulted in a significant conditioned place preference (CPP) in rats.
  • Low doses of Tyr-W-MIF-1 (25-100 microg) did not alter morphine-induced CPP, indicating a lack of opiate antagonistic effects.

Conclusions:

  • Tyr-W-MIF-1 exhibits opiate agonistic properties in the CPP test at a high dose.
  • Tyr-W-MIF-1 lacks opiate antagonistic properties at lower doses within the CPP paradigm.