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Acitretin in combination with UVB or PUVA.

M Lebwohl1

  • 1Department of Dermatology, The Mount Sinai School of Medicine, New York, NY 10029, USA.

Journal of the American Academy of Dermatology
|August 25, 1999
PubMed
Summary

Combining acitretin with phototherapy (PUVA or UVB) offers advantages for psoriasis treatment. This combination therapy uses lower doses, reduces side effects, and speeds up clearing compared to single treatments.

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Area of Science:

  • Dermatology
  • Photomedicine

Background:

  • Acitretin monotherapy (50 mg/day) for psoriasis is moderately effective but causes side effects.
  • Phototherapy (UVB or PUVA) requires multiple sessions over months and has dose-limiting side effects.
  • Psoriasis treatment often involves balancing efficacy with managing adverse effects.

Purpose of the Study:

  • To evaluate the advantages of combining acitretin with phototherapy for psoriasis treatment.
  • To compare the efficacy and side effect profile of combination therapy versus monotherapy.
  • To determine if combination therapy can improve treatment outcomes and reduce patient burden.

Main Methods:

  • Combination therapy involving acitretin and phototherapy (psoralen-ultraviolet A [PUVA] or ultraviolet B [UVB]).
  • Comparison of outcomes with monotherapy (acitretin alone or phototherapy alone).
  • Assessment of treatment effectiveness, side effects, and treatment duration.

Main Results:

  • Combination therapy allows for lower, more effective doses of both acitretin and phototherapy.
  • Reduced side effects are observed when using the combined treatment approach.
  • Psoriasis clearing is significantly faster with combination therapy, reducing overall treatment time and phototherapy visits.
  • Patients unresponsive to monotherapy often achieve significant clearing with combination therapy.

Conclusions:

  • Combination therapy of acitretin and phototherapy is more effective and tolerable than monotherapy for psoriasis.
  • This approach offers a faster and potentially safer treatment option for managing psoriasis.
  • Combination therapy can improve outcomes for patients who do not respond adequately to single-modality treatments.

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