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Related Experiment Videos

A closed rebreathing system for dose maintenance during Partial Liquid Ventilation.

B Schrader1, D Westenskow, S Kofoed

  • 1Department of Anesthesiology, University of Utah, Salt Lake City, USA.

Biomedical Instrumentation & Technology
|August 25, 1999
PubMed
Summary

A new closed rebreathing system for Partial Liquid Ventilation (PLV) minimizes perflubron (PFB) loss, reducing redosing and achieving significant dose savings during mechanical ventilation for acute respiratory failure.

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Area of Science:

  • Respiratory Physiology
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Partial Liquid Ventilation (PLV) uses perfluorochemical (PFC) liquids like perflubron (PFB) to treat acute respiratory failure.
  • Evaporative loss of PFB during PLV necessitates frequent redosing, increasing treatment costs and complexity.
  • Existing PLV methods face challenges in maintaining consistent PFB dosage due to vapor loss.

Purpose of the Study:

  • To develop and evaluate a novel closed rebreathing system to minimize PFB evaporative loss during PLV.
  • To assess the system's ability to maintain stable PFB dosage and reduce redosing requirements.
  • To validate the system's performance through in-vitro and in-vivo studies.

Main Methods:

  • A closed rebreathing system was designed with two compartments separated by a flexible bag, isolating the patient's breathing circuit from the ventilator.

Related Experiment Videos

  • The system utilizes feedback control for oxygen levels and pressure to maintain constant gas volume and airway humidification.
  • Performance was evaluated using in-vitro experiments and in-vivo PLV studies in pigs, monitoring key respiratory parameters.

    • Main Results:

    • The closed rebreathing system effectively confined PFB vapor, significantly minimizing evaporative loss.
    • Stable PFB dosage was maintained, reducing the need for frequent redosing procedures.
    • Approximately 90% savings in PFB dose were achieved, demonstrating high system efficiency.

    Conclusions:

    • The developed closed rebreathing system is a safe and effective method for minimizing PFB loss during PLV.
    • This innovation leads to substantial dose savings and simplifies the management of PLV therapy.
    • The system holds promise for improving the clinical application and economic viability of PLV for acute respiratory failure.