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Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state:
H Mashiko1, S Niwa, H Kumashiro
1Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima-City, Japan.
Psychiatry and Clinical Neurosciences
|August 25, 1999
Abstract:
This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.