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Related Experiment Videos

Hemispheric-synchronisation during anaesthesia: a double-blind randomised trial using audiotapes for intra-operative

P Kliempt1, D Ruta, S Ogston

  • 1Department of Epidemiology, Ninewells Hospital, Dundee DD1 9SY, UK.

Anaesthesia
|August 25, 1999
PubMed
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Hemispheric-synchronised sounds significantly reduced intraoperative fentanyl requirements in patients under general anesthesia. This suggests auditory stimulation can be an effective adjunct for pain management during surgery.

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Pain Management

Background:

  • Pain perception during surgery under general anesthesia can be modulated by various factors.
  • Auditory stimuli, including music and specific sound patterns, have been explored for their potential effects on pain and anxiety.
  • Objective measures are needed to quantify the antinociceptive effects of non-pharmacological interventions during surgical procedures.

Purpose of the Study:

  • To investigate the antinociceptive effect of hemispheric-synchronised sounds compared to classical music and blank tape in patients undergoing surgery.
  • To evaluate the efficacy of auditory stimulation as an adjunct to general anesthesia for pain control.
  • To use fentanyl requirements as a quantitative measure of nociception control.

Main Methods:

Related Experiment Videos

  • A double-blind, randomized study involving 76 patients (ASA 1 or 2, aged 18-75 years).
  • Standardized general anesthesia (propofol, nitrous oxide, isoflurane, fentanyl) with spontaneous breathing via laryngeal mask.
  • Patients were allocated to receive hemispheric-synchronised sounds, classical music, or a blank tape.

Main Results:

  • Patients exposed to hemispheric-synchronised sounds required significantly less fentanyl (mean 28 µg) compared to those listening to classical music (124 µg) or blank tape (126 µg) (p < 0.001).
  • The reduced fentanyl requirement in the hemispheric-synchronised sound group remained statistically significant after controlling for age and sex via regression analysis.
  • This indicates a potent antinociceptive effect of hemispheric-synchronised sounds during general anesthesia.

Conclusions:

  • Hemispheric-synchronised sounds demonstrate a significant antinociceptive effect in surgical patients under general anesthesia.
  • Auditory stimulation with hemispheric-synchronised sounds can potentially reduce the need for opioid analgesics during surgery.
  • This finding supports the use of tailored auditory interventions as a complementary strategy in pain management during anesthesia.