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Mesenteric vein thrombosis due to factor V Leiden gene mutation
M Bergenfeldt1, P J Svensson, A Borgström
1Department of Surgery, University Hospital of Malmö, Sweden.
The British Journal of Surgery
|August 25, 1999
Summary
Activated protein C resistance, a genetic mutation in coagulation factor V, is linked to mesenteric venous thrombosis. This finding may explain primary cases of this rare abdominal pain cause.
Area of Science:
- Medical research
- Hematology
- Vascular medicine
Background:
- Mesenteric venous thrombosis is a rare condition causing acute abdominal pain.
- Coagulation abnormalities are potential underlying causes.
Observation:
- Four consecutive patients with MVT underwent hematological evaluation.
- Diagnostic methods included surgery and ultrasonography.
Findings:
- All four patients exhibited activated protein C resistance due to a specific mutation in the coagulation factor V gene.
- One patient died post-surgery; the other three survived with long-term anticoagulation therapy.
Implications:
- Activated protein C resistance may be a significant pathogenetic factor in primary MVT.
- Genetic screening for factor V mutations could aid in MVT risk assessment.