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Mesenteric vein thrombosis due to factor V Leiden gene mutation
M Bergenfeldt1, P J Svensson, A Borgström
1Department of Surgery, University Hospital of Malmö, Sweden.
Background:
Mesenteric venous thrombosis is a rare cause of acute abdominal pain that may be the result of coagulation abnormalities.
Methods:
Four consecutive patients with mesenteric venous thrombosis underwent haematological evaluation.
Results:
All four had activated protein C resistance resulting from a single mutation in the gene coding for coagulation factor V. Three had surgery; in one patient the diagnosis was made by ultrasonography. One of the patients who had surgery died but the other three survived and were treated with long-term anticoagulation.
Conclusion:
Activated protein C resistance may be an important pathogenetic factor in primary mesen-teric vein thrombosis.