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Updated: Aug 9, 2026
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Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
Published on: May 31, 2018
Mushrooms, tumors, and immunity
A T Borchers1, J S Stern, R M Hackman
1Division of Rheumatology/Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616-8660, USA.
Summary
Mushroom compounds, especially beta-glucans, show potential for modulating the immune system and inhibiting tumors. Further research is needed to understand their molecular mechanisms and therapeutic applications.
Area of Science:
- Mycology
- Immunology
- Pharmacology
Background:
- Mushrooms have a long history of medicinal use.
- Mushroom extracts are popular nutraceuticals, but scientific evidence is limited.
- Existing studies on mushroom bioactivity are primarily in animal models.
Purpose of the Study:
- To critically review the scientific literature on the biological effects of mushrooms.
- To integrate the nutraceutical potential of mushrooms with basic science.
- To explore the immunomodulatory and antitumor mechanisms of mushroom compounds.
Main Methods:
- Review of existing scientific data on whole mushrooms and isolated compounds.
- Focus on (1-->3)-beta-D-glucans and their immunomodulatory effects.
- Analysis of studies involving T cells and macrophages in mushroom-mediated antitumor activity.
Main Results:
- Certain mushroom polysaccharides, particularly beta-glucans, appear to mediate antitumor effects via T cells and macrophages.
- Effectiveness varies among different mushroom species and glucan structures.
- Glucans influence cytokine expression and cellular responses, but mechanisms are not fully elucidated.
Conclusions:
- Mushroom-derived beta-glucans show promise as immunomodulators and potential antitumor agents.
- Understanding the molecular interactions of glucans with target cells is crucial for advancing research.
- Further investigation is required to clarify the mechanisms underlying mushroom bioactivity and therapeutic potential.
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