Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sympathetic overactivity from fenfluramine-phentermine overdose.

R Koury1, C K Stone, J S Stapczynski

  • 1Department of Emergency Medicine, University of Kentucky Medical Center, Lexington 40536-0236, USA.

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
|August 26, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC.

Nature·2026
Same author

Australian Youth Self-Harm Atlas: spatial modelling and mapping of self-harm prevalence and related risk and protective factors to inform youth suicide prevention strategies.

Epidemiology and psychiatric sciences·2024
Same author

Infusion of Non-HLA-Matched Off-the-Shelf <i>Ex Vivo</i> Expanded Cord Blood Progenitors in Patients Undergoing Cord Blood Transplantation: Result of a Phase II Clinical Trial.

Frontiers in cell and developmental biology·2022
Same author

Mad River Valley Dental Association.

The Dental register·2021
Same author

Qiviut cortisol reflects hypothalamic-pituitary-adrenal axis activity in muskoxen (Ovibos moschatus).

General and comparative endocrinology·2021
Same author

Spinal Stenosis in Familial Transthyretin Amyloidosis.

Journal of neuromuscular diseases·2019
Same journal

Response to the letter 'Mental illness and epilepsy are not attributable to out-of-hospital resuscitation after cardiac arrest unless other causes have been ruled out'.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same journal

Mental illness and epilepsy are not attributable to out-of-hospital resuscitation after cardiac arrest unless other causes have been ruled out.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same journal

The effect of oxygen administration on systemic oxidative stress in patients presenting in the emergency department: a prospective cohort study.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same journal

Trends in ketamine-related emergency department presentations across European centres: a Euro-DEN Plus Study (2013-2023).

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same journal

Low-value care in prehospital emergency medicine: the unspoken challenge.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
Same journal

Making the case for Paediatric Emergency Medicine in Europe.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine·2026
See all related articles

This case report details a severe fenfluramine-phentermine overdose presenting with extreme hyperadrenergic symptoms and self-inflicted burns. The patient required extensive medical intervention, including mechanical ventilation and skin grafts, highlighting the drug

Area of Science:

  • Emergency Medicine
  • Clinical Toxicology
  • Pharmacology

Background:

  • Fenfluramine-phentermine, a combination once used for weight loss, carries risks of significant adverse effects.
  • Understanding the spectrum of overdose toxicity is crucial for emergency department management.

Observation:

  • A young male presented with severe hyperadrenergic symptoms including tachycardia, fever, and combativeness following fenfluramine-phentermine ingestion.
  • The patient sustained self-inflicted second-degree burns, complicating the clinical picture.
  • Adult respiratory distress syndrome (ARDS) developed, necessitating prolonged mechanical ventilation.

Findings:

  • The overdose mimicked a profound 'sympathetic storm,' a presentation not previously documented with this drug combination.

Related Experiment Videos

  • Management required a multi-faceted approach including sedatives, paralytics, adrenergic antagonists, and mechanical ventilation.
  • The patient underwent skin grafting for extensive burns and had a 26-day hospital stay.

    • Implications:

    • This case underscores the potential for severe, life-threatening toxicity from fenfluramine-phentermine overdose.
    • Clinicians should be vigilant for hyperadrenergic crises and associated complications like burns and ARDS.
    • Further research into the neuroadrenergic effects of fenfluramine-phentermine is warranted.