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Multiple perifollicular fibromas.

D B McKenna1, C Barry-Walsh, M Leader

  • 1Department of Dermatology, Beaumont Hospital, Dublin, Ireland.

Journal of the European Academy of Dermatology and Venereology : JEADV
|August 26, 1999
PubMed
Summary
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Multiple perifollicular fibromas, benign hair follicle tumors, can be inherited. This case suggests an autosomal dominant inheritance pattern, with no associated malignancy observed.

Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Background:

  • Perifollicular fibroma is a benign mesodermal tumor originating from the hair follicle.
  • It presents as solitary or multiple lesions, often clinically resembling other pilar tumors.
  • Association with internal malignancy, particularly adenomatous colonic polyps, has been noted for adnexal tumors.

Observation:

  • This report details a patient presenting with multiple perifollicular fibromas.
  • The patient exhibited no concurrent internal malignancy at the time of observation.
  • A family pedigree was analyzed in conjunction with the clinical presentation.

Findings:

  • The clinical presentation and family history suggest a potential genetic basis for multiple perifollicular fibromas.

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  • The observed inheritance pattern in the family is suggestive of autosomal dominant transmission.
  • No evidence of associated malignancy was found in the index patient.

    • Implications:

    • Understanding the inheritance patterns of perifollicular fibromas is crucial for genetic counseling.
    • Further research may elucidate the specific genetic factors involved in the development of these tumors.
    • Distinguishing between sporadic and familial cases is important for risk assessment regarding associated malignancies.