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Correlation between circulating stromal cell-derived factor 1 levels and CD4+ cell count in human immunodeficiency
C A Derdeyn1, C Costello, J M Kilby
1Department of Pathology, University of Alabama at Birmingham, 35233, USA.
AIDS Research and Human Retroviruses
|August 26, 1999
Summary
Stromal cell-derived factor 1 (SDF-1) levels correlate with CD4+ cell counts in HIV-1 infection. Lower SDF-1 may indicate disease progression, but antiretroviral therapy did not alter levels in advanced cases.
Area of Science:
- Immunology
- Virology
- Molecular Biology
Background:
- Stromal cell-derived factor 1 (SDF-1) is the natural ligand for CXCR4, a coreceptor for certain HIV-1 strains.
- Understanding SDF-1's role in HIV-1 infection is crucial for disease progression insights.
Purpose of the Study:
- To investigate the relationship between plasma/serum SDF-1 protein levels and CD4+ cell counts in HIV-1-infected individuals.
- To explore potential links between SDF-1 levels and HIV-1 disease stage.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify SDF-1 protein concentrations.
- Samples were analyzed from 31 HIV-1-seronegative and 79 HIV-1-infected subjects.
- SDF-1 mRNA expression was analyzed in lymph node biopsies from HIV-1-infected individuals.
Main Results:
- HIV-1-infected subjects showed a direct correlation between SDF-1 levels and CD4+ cell counts.
- Individuals with CD4+ cell counts <50 cells/µL had significantly lower mean SDF-1 levels compared to controls and those with higher CD4+ counts.
- Antiretroviral therapy did not significantly alter SDF-1 levels in nine subjects with advanced HIV-1 disease.
Conclusions:
- Lower SDF-1 levels in HIV-1-infected individuals may be associated with disease progression.
- Stromal cells in lymph node medullary cords express SDF-1 mRNA, suggesting a potential source.
- Further research is warranted to elucidate the precise role of SDF-1 in HIV-1 pathogenesis.