Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoids as potential new analgesics.

J A Fuentes1, M Ruiz-Gayo, J Manzanares

  • 1Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.

Life Sciences
|August 26, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabidiol modulates brain molecular alterations, gut microbiota dysbiosis and alcohol self-administration in a mouse model of fetal alcohol spectrum disorder.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

ESTraS, an easy and simple tracking system for assessing rodent behavior.

Behavior research methods·2025
Same author

Role of CB2 cannabinoid receptor in the development of food addiction in male mice.

Neurobiology of disease·2023
Same author

Effect of a high-fat diet and leptin on STAT3 phosphorylation in hippocampal astrocytes.

Neuroreport·2022
Same author

Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice.

Psychoneuroendocrinology·2021
Same author

Long-term Follow-up of a Randomized Trial of Tacrolimus or Cyclosporine A Microemulsion in Children Post Liver Transplantation.

Transplantation direct·2021

Cannabinoids offer therapeutic pain relief by interacting with the newly discovered cannabinoid system. Combining cannabinoid and opioid drugs may enhance this analgesic effect for a novel pain management strategy.

Area of Science:

  • Pharmacology and Neuroscience
  • Pain Management Research

Background:

  • Cannabinoids possess significant analgesic properties, demonstrated in both animal models and human studies.
  • A novel neuromodulatory system involving cannabinoid receptors and endogenous agonists has been identified, proposed as an endogenous pain control mechanism.
  • Evidence suggests an interaction between the cannabinoid and opioid systems, both relevant to nociception.

Purpose of the Study:

  • To explore the therapeutic potential of cannabinoids for analgesia.
  • To investigate the interaction between the cannabinoid and opioid systems in pain modulation.
  • To propose a new analgesic strategy based on simultaneous receptor activation.

Main Methods:

  • Review of existing scientific literature on cannabinoid and opioid pharmacology.

Related Experiment Videos

  • Analysis of experimental data demonstrating antinociceptive effects.
  • Examination of evidence for cannabinoid-opioid system interactions.

    • Main Results:

    • Cannabinoids effectively produce antinociception.
    • The cannabinoid system represents a significant endogenous pain control pathway.
    • Opioids, both exogenous and endogenous, potentiate cannabinoid-induced antinociception.

    Conclusions:

    • Cannabinoids exhibit promising analgesic properties with therapeutic potential.
    • The interaction between cannabinoid and opioid systems offers a new avenue for pain management.
    • Simultaneous activation of opioid and cannabinoid receptors presents a novel analgesic strategy.