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Cannabinoids, hippocampal function and memory.

R E Hampson1, S A Deadwyler

  • 1Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083, USA.

Life Sciences
|August 26, 1999
PubMed
Summary
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Cannabinoids like WIN 55,212-2 impair short-term memory by affecting hippocampal CB1 receptors. These receptors are crucial for processing and maintaining information in tasks like the delayed nonmatch to sample (DNMS) test.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Previous research indicates delta9-tetrahydrocannabinol (THC) impairs short-term memory.
  • Cannabinoids interact with CB1 receptors in the brain.

Purpose of the Study:

  • To investigate the effects of the cannabinoid WIN 55,212-2 on short-term memory using the delayed nonmatch to sample (DNMS) task.
  • To compare cannabinoid effects with hippocampal and retrohippocampal lesions.

Main Methods:

  • Administered WIN 55,212-2 to subjects and assessed performance on the DNMS task.
  • Utilized CB1 receptor antagonist SR141716A and GABA(B) receptor antagonist phaclofen to block specific receptor actions.
  • Compared behavioral effects with effects of hippocampal and retrohippocampal lesions.

Main Results:

Related Experiment Videos

  • Low doses of WIN 55,212-2 caused delay-dependent deficits in the DNMS task, similar to hippocampal lesions.
  • High doses of WIN 55,212-2 mimicked effects of combined hippocampal and retrohippocampal lesions.
  • The high dose deficit was sensitive to SR141716A and phaclofen, suggesting involvement of CB1 and GABA(B) receptors.

Conclusions:

  • CB1 receptors on hippocampal neurons are involved in processing task-specific information within a trial.
  • CB1 receptors on hippocampal GABAergic interneurons and in retrohippocampal areas influence inter-trial information maintenance.