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Possible mechanism of action of vanadium ions as an antidiabetic agent
K Terziyski1, R Tzenova, E Milieva
1Department of Physiology and Biophysics, Higher Medical Institute, Plovdiv.
Folia Medica
|August 27, 1999
Abstract:
Vanadium compounds, at much higher concentrations than they are typically ingested, are being considered for use in the treatment of diabetes mellitus. They exert an insulin-mimetic effect in an insulin-receptor-independent manner. In our study we obtained new data about the vanadium insulin-receptor-independent mechanism of action on cell membranes. When rat stomach smooth muscle samples are treated with NH4VO3 (10(-7) divided by 10(-5) this action is possibly exhibited with increased influx of Ca2+ through VDCa2+C.