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Updated: Oct 19, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
Published on: July 9, 2016
New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies
1Institut für Pharmakologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany. stoff@zedat.fu-berlin.de
Abstract:
A huge number of receptors signals through heterotrimeric G-proteins to regulate a wide variety of physiological processes. The ability to modify G-protein expression in vivo provides a powerful new tool to analyze the function of G-protein-mediated signalling pathways. Genetic ablation of G-protein alpha-subunit genes is continuing to give new insights into the physiological roles of heterotrimeric G-proteins. This review highlights recent advances resulting from such genetic approaches to the study of G-protein-mediated signalling.
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