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Activated Borna disease virus in affective disorders.

R Ferszt1, E Severus, L Bode

  • 1Department of Gerontopsychiatry, Free University of Berlin, Germany. ferszt@zedat.fu-berlin.de

Pharmacopsychiatry
|August 27, 1999
PubMed
Summary
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Borna disease virus (BDV) antigens were found more frequently in psychiatric patients with major depressive episodes, particularly those with recurrent depression or bipolar disorder. This suggests a potential link between BDV infection and affective disorders.

Area of Science:

  • Neurovirology
  • Psychiatry
  • Immunology

Background:

  • Borna disease virus (BDV) is an animal pathogen linked to behavioral changes.
  • Previous research indicated a high prevalence of BDV antibodies, antigens (BDVAGs), and RNA in psychiatric patients, especially those with affective disorders.

Purpose of the Study:

  • To further characterize the Borna disease virus antigen (BDVAG) cohort in psychiatric patients using clinical parameters.
  • To investigate the association between BDVAG and clinical features in major depressive episodes.

Main Methods:

  • Examined the prevalence of BDVAG in peripheral mononuclear leukocytes of patients experiencing a major depressive episode.
  • Conducted further clinical analysis on a subgroup of these patients.

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Main Results:

  • A significant difference in BDVAG prevalence was observed between psychiatric inpatients with major depressive episodes and control individuals.
  • BDVAG was more frequent in patients with recurrent major depression or bipolar disorder compared to other psychiatric disorders.
  • Increased BDVAG was positively correlated with the number of previous depressive episodes and symptoms of fatigue and concentration difficulties.

Conclusions:

  • The elevated BDVAG rate, particularly in fatigued patients with recurrent major depression or bipolar disorder, might indicate a non-specific immunosuppressive effect.
  • The potential role of this neurotropic virus in the pathogenesis of certain affective disorders warrants further investigation.