Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diminished vasoconstrictive function caused by long-term nonpulsatile left heart bypass.

T Nishimura1, E Tatsumi, T Nishinaka

  • 1Department of Artificial Organs, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.

Artificial Organs
|August 27, 1999
PubMed
Summary

Prolonged nonpulsatile left heart bypass (NPLHB) in goats impaired vascular constrictive function. The vascular system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth.

Science (New York, N.Y.)·2022
Same author

Variations in color and reflectance on the surface of asteroid (101955) Bennu.

Science (New York, N.Y.)·2020
Same author

Sample collection from asteroid (162173) Ryugu by Hayabusa2: Implications for surface evolution.

Science (New York, N.Y.)·2020
Same author

An artificial impact on the asteroid (162173) Ryugu formed a crater in the gravity-dominated regime.

Science (New York, N.Y.)·2020
Same author

Journal of Artificial Organs 2019: the year in review : Journal of Artificial Organs Editorial Committee.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2020

Area of Science:

  • Cardiovascular Physiology
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Left heart bypass (LHB) is a critical intervention for cardiac support.
  • Understanding the systemic vascular effects of different LHB modes is essential.

Purpose of the Study:

  • To investigate the impact of prolonged nonpulsatile left heart bypass (NPLHB) on systemic vascular function.
  • To assess changes in vascular constrictive response under NPLHB.

Main Methods:

  • Adult goats underwent pulsatile left heart bypass (PLHB) followed by 4 weeks of NPLHB.
  • Systemic vascular resistance (SVR) and plasma norepinephrine levels were measured.
  • Vascular constrictive response (deltaSVR) to norepinephrine injection was evaluated.

Related Experiment Videos

Main Results:

  • Systemic vascular resistance and plasma norepinephrine levels remained stable.
  • The constrictive response (deltaSVR) to norepinephrine significantly decreased during prolonged NPLHB.
  • This diminished response was evident by the third and fourth weeks of NPLHB.

Conclusions:

  • Prolonged NPLHB significantly impairs the constrictive function of the systemic vascular system.
  • The findings suggest potential long-term vascular maladaptations associated with NPLHB.