Related Experiment Videos
Spinal cord involvement in pediatric systemic lupus erythematosus: case report and literature review
1Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Clinical and Experimental Rheumatology
|August 28, 1999
Insights
Transverse myelitis, a rare systemic lupus erythematosus complication, occurred in the youngest patient on record. Treatment with prednisone and cyclophosphamide led to clinical improvement, supported by literature review.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse neurological manifestations.
- Transverse myelitis is a rare but severe neurological complication associated with SLE.
Observation:
- This report details the case of the youngest patient diagnosed with transverse myelitis in the context of SLE.
- The patient presented with symptoms indicative of spinal cord inflammation.
Findings:
- Clinical improvement was observed following treatment with prednisone and cyclophosphamide.
- A comprehensive review of English literature from 1966 to the present on SLE-associated transverse myelitis was conducted.
Implications:
- This case highlights the potential for early-onset transverse myelitis in SLE patients.
- The findings underscore the efficacy of immunosuppressive therapy in managing this serious complication.
- Further research into early diagnosis and management strategies for pediatric SLE neurological complications is warranted.
Abstract:
Transverse myelitis is a rare but serious complication of systemic lupus erythematosus (SLE). We describe the youngest patient with transverse myelitis ever recorded in SLE. Clinical improvement was observed after prednisone and cyclophosphamide therapy. The English language literature from 1966 to the present on the subject are reviewed.