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Thermodynamic ionization constants of antihypertensive drugs
Y K Agrawal1, S K Menon, F Majumudar
1Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India.
Bollettino Chimico Farmaceutico
|August 28, 1999
Abstract:
The thermodynamic ionization constants (pKa) of indapamide, clonidine and methyldopa have been determined at 25 degrees C and 35 degrees C by pH titration technique. The pKa varies linearly with mole fraction of dioxane. The thermodynamic parameters have been calculated.