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Related Experiment Videos

Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation.

D J Handelsman1, J A Spaliviero, J M Simpson

  • 1Department of Medicine, University of Sydney, New South Wales, Australia. djh@med.usyd.edu.au

Endocrinology
|August 28, 1999
PubMed
Summary

Testosterone can induce and maintain spermatogenesis in mice lacking gonadotropins. Maintaining spermatogenesis requires significantly lower testosterone levels than inducing it, suggesting different molecular mechanisms are involved.

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Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Molecular Biology

Background:

  • Testosterone (T) alone can induce spermatogenesis in gonadotropin-deficient hpg mice.
  • Previous studies established a 1-cm T implant for full spermatogenesis induction.

Purpose of the Study:

  • To investigate the quantitative androgen requirement for maintaining spermatogenesis.
  • To test if the androgenic threshold for induction and maintenance are the same.

Main Methods:

  • Inducing spermatogenesis in hpg mice with T implants.
  • Assessing spermatogenesis regression after T withdrawal.
  • Evaluating maintenance of spermatogenesis with reduced T doses.

Main Results:

Related Experiment Videos

  • Spermatogenesis regressed within 3-4 weeks of T withdrawal.
  • Full spermatogenesis maintenance observed with 0.06 cm T implants.
  • Elongated spermatids maintained with 0.25 cm T implants.

    • Conclusions:

    • The androgenic threshold to maintain spermatogenesis is significantly lower than for induction.
    • Distinct mechanisms may underlie T-induced spermatogenesis initiation versus maintenance.
    • Androgen-dependent meiotic genes are key to understanding T's role in spermatogenesis.