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Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
W C Groutas1, N M Schechter, S He
1Department of Chemistry, Wichita State University, KS 67260, USA.
Bioorganic & Medicinal Chemistry Letters
|August 28, 1999
Abstract:
A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.