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7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid: a novel blue fluorescent dye for protein labeling
W Y Leung1, P A Trobridge, R P Haugland
1Molecular Probes, Inc, Eugene, OR 97402, USA.
Bioorganic & Medicinal Chemistry Letters
|August 28, 1999
Abstract:
7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid (AMCA-S, also called Alexa 350) 2 was synthesized as a new water-soluble blue fluorescent dye for protein labeling. Compared with its nonsulfonated counterpart (AMCA) 1 the new dye gave significantly higher fluorescence quantum yields on proteins.