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Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists
S C Bergmeier1, D J Lapinsky, R B Free
1Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus 43210-1291, USA.
Bioorganic & Medicinal Chemistry Letters
|August 28, 1999
Abstract:
We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors.