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Adoptive immunotherapy for cutaneous T-cell lymphomas
1Royal Marsden Hospital, Sutton, Surrey, UK.
The pathology of cutaneous T-cell lymphomas is predominantly in the skin. Allogeneic bone-marrow transplantation results in graft-versus-host disease involving the skin in many cases. It has been suggested that it would be interesting to see the effect of allotransplantation, even though no series has been reported so far. Adoptive immunotherapy with donor lymphocyte infusions has been increasingly used to treat post-transplant relapse and even prevention. The present hypothesis suggests that infusion of human leucocyte antigen (HLA)-matched donor lymphocyte infusions would result in a graft-versus-leukemia/lymphoma (GVL) effect in these disorders. Therefore, clinical trials are suggested.
The pathology of cutaneous T-cell lymphomas is predominantly in the skin. Allogeneic bone-marrow transplantation results in graft-versus-host disease involving the skin in many cases. It has been suggested that it would be interesting to see the effect of allotransplantation, even though no series has been reported so far. Adoptive immunotherapy with donor lymphocyte infusions has been increasingly used to treat post-transplant relapse and even prevention. The present hypothesis suggests that infusion of human leucocyte antigen (HLA)-matched donor lymphocyte infusions would result in a graft-versus-leukemia/lymphoma (GVL) effect in these disorders. Therefore, clinical trials are suggested.