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CD69 and regulation of the immune function.
R Marzio1, J Mauël, S Betz-Corradin
1Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Italy.
Immunopharmacology and Immunotoxicology
|August 31, 1999
Summary
CD69, a transmembrane glycoprotein, is expressed on various immune cells and plays a role in hematopoietic cell biology. Its involvement in diseases like rheumatoid arthritis suggests therapeutic potential.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- CD69, also known as activation inducer molecule, is a type II transmembrane glycoprotein.
- It belongs to the signal transducing receptors family and features a C-type lectin binding domain.
- CD69 is expressed on various immune cells, including T and B lymphocytes, NK cells, macrophages, and monocytes.
Purpose of the Study:
- To summarize the known information about CD69, including its structure, expression, and potential roles.
- To highlight the involvement of CD69 in hematopoietic cell biology and disease pathogenesis.
Main Methods:
- Literature review and synthesis of existing research on CD69.
- Analysis of CD69 expression patterns across different cell types and conditions.
Main Results:
- CD69 expression is induced in vitro on most hematopoietic lineages and constitutively expressed on human monocytes, platelets, and Langerhans cells.
- Crosslinking CD69 induces intracellular signals, suggesting a functional role for the receptor.
- A specific ligand for CD69 has not yet been identified.
Conclusions:
- CD69's wide cellular distribution and signaling capabilities suggest a significant role in immune cell function.
- Emerging evidence links CD69 to the pathogenesis of inflammatory diseases such as rheumatoid arthritis, chronic liver diseases, asthma, and AIDS.