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Defining optimal body iron.

J D Cook1

  • 1Department of Medicine, University of Kansas Medical Center, Kansas City 66160, USA. jcook1@kumc.edu

The Proceedings of the Nutrition Society
|August 31, 1999
PubMed
Summary
This summary is machine-generated.

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Iron deficiency negatively impacts development and performance. Optimal iron nutrition, defined by normal hemoglobin and iron biomarkers like serum transferrin receptor, ensures adequate tissue iron supply and prevents deficiency.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Hematology

Background:

  • Iron deficiency (Fe lack) causes significant health issues, including developmental and cognitive impairments.
  • These health problems are often linked to anemia, but milder forms of iron deficiency may exist without it.

Purpose of the Study:

  • To define adequate and optimal iron nutrition.
  • To evaluate various laboratory measurements for identifying iron deficiency, especially milder forms.

Main Methods:

  • Review of existing literature on iron deficiency and its health consequences.
  • Analysis of laboratory markers such as serum ferritin, transferrin saturation, and serum transferrin receptor.
  • Comparison of the effectiveness of different markers in identifying iron deficiency.

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Main Results:

  • Adequate iron nutrition is characterized by normal hemoglobin levels.
  • Optimal iron nutrition requires sufficient body iron to prevent tissue iron limitation (Fe-deficient erythropoiesis).
  • Serum transferrin receptor concentration is a preferred marker for early iron deficiency detection, unaffected by inflammation.

Conclusions:

  • Optimal iron nutrition is best defined by normal concentrations of hemoglobin, serum ferritin, and serum transferrin receptor.
  • Serum transferrin receptor is a reliable indicator of iron status, reflecting the initial cellular response to declining iron supply.
  • Accurate assessment of iron status is crucial for preventing associated health liabilities.