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Updated: Oct 19, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
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Prothrombotic factors, endothelial function and left ventricular hypertrophy in isolated systolic hypertension

G Y Lip1, A D Blann, D G Beevers

  • 1University Department of Medicine, City Hospital, Birmingham, UK. g.y.h.lip@bham.ac.uk

Journal of Hypertension
|August 31, 1999
PubMed

Insights

Individuals with isolated systolic hypertension (ISH) show similar blood clotting and endothelial dysfunction markers as those with systolic-diastolic hypertension (SDH). This suggests ISH also increases the risk of thrombotic events like stroke and heart attack.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Hypertension Research

Background:

  • Systolic-diastolic hypertension (SDH) increases thrombotic complication risk.
  • Isolated systolic hypertension (ISH) also presents significant cardiovascular risk.
  • ISH may involve a prothrombotic state similar to SDH.

Purpose of the Study:

  • To investigate if ISH patients exhibit a prothrombotic state comparable to SDH patients.
  • To compare echocardiographic parameters between ISH and SDH patients.

Main Methods:

  • Measured hemorheology, endothelial dysfunction, thrombogenesis, and platelet activation in ISH, SDH, and control groups.
  • Compared echocardiographic parameters between ISH and SDH patients.

Main Results:

  • Plasma viscosity, von Willebrand factor, plasminogen activator inhibitor-1, and lipoprotein(a) were elevated in ISH and SDH versus controls.
  • SDH patients showed higher plasma fibrinogen and hematocrit than controls.
  • Echocardiographic parameters were similar between ISH and SDH patients.

Conclusions:

  • Individuals with ISH demonstrate prothrombotic factor and endothelial dysfunction abnormalities similar to SDH.
  • Echocardiographic parameters in ISH are comparable to those in SDH.
  • These findings support the increased risk of thrombotic events in ISH patients.
Abstract

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