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Infection control in gene therapy.

M E Evans¹, J A Lesnaw

¹University of Kentucky Medical Center, T.H. Morgan School of Biological Sciences, University of Kentucky, Lexington 40536-0293, USA.

Infection Control and Hospital Epidemiology

|August 31, 1999

Summary

Gene therapy uses viral vectors to treat diseases. This review covers common vectors and provides infection control recommendations for healthcare settings.

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Area of Science:

* Molecular Biology
* Infectious Diseases
* Medical Virology

Background:

* Gene therapy is an emerging treatment for inherited and acquired diseases.
* Viral vectors are crucial for delivering therapeutic genes.
* Clinical application of gene therapy necessitates understanding vector safety.

Purpose of the Study:

* To review common viral vectors used in gene therapy.
* To highlight key aspects of these vectors for infection control.
* To provide recommendations for infection control practices.

Main Methods:

* Literature review of viral vectors in gene therapy.
* Summary of characteristics of common viral vectors (retroviruses, adenoviruses, adeno-associated viruses, vaccinia viruses, herpesviruses).
* Analysis of infection control implications.

Main Results:

* Several types of viruses are employed as gene transfer vectors.
* These vectors are transitioning from laboratory and animal studies to clinical use.
* Infection control practitioners require knowledge of these agents.

Conclusions:

* Gene therapy holds promise for treating numerous diseases.
* Understanding viral vector properties is essential for safe clinical implementation.
* Proactive infection control strategies are necessary for gene therapy administration.

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