Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis and carcinogenesis.

A H Wyllie1, C O Bellamy, V J Bubb

  • 1Department of Pathology, University of Edinburgh Medical School, UK.

British Journal of Cancer
|August 31, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2024
Same author

A comprehensive phylogeny helps clarify the evolutionary history of host breadth and lure response in the Australian Dacini fruit flies (Diptera: Tephritidae).

Molecular phylogenetics and evolution·2022
Same author

Short communication: Effect of a citrus extract in lactating dairy cows.

Journal of dairy science·2017
Same author

Unisexual broods and sex ratios in a polyembryonic encyrtid parasitoid (Copidosoma sp.: Hymenoptera).

Oecologia·2017
Same author

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2016
Same author

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes.

Oncogene·2014
Same journal

Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.

British journal of cancer·2026
Same journal

Altretamine induces ferroptosis in small cell lung cancer by promoting epigenetic silencing and lysosomal degradation of GPX4.

British journal of cancer·2026
Same journal

Revisiting retinoic acid in AML therapy: mechanisms of action and rational combination strategies.

British journal of cancer·2026
Same journal

De novo cancer-related mortality after solid organ transplantation in England: the EpCOT study.

British journal of cancer·2026
Same journal

Planetary Health Diet Index and breast cancer risk.

British journal of cancer·2026
Same journal

Can national lung cancer screening programs be implemented without exacerbating social disparities?

British journal of cancer·2026
See all related articles

Apoptosis, a programmed cell death process, involves common structural changes and caspase activation. DNA damage regulation, crucial for preventing mutated cells, may involve p53 and MSH-2 proteins.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Genetics

Background:

  • Apoptosis is a fundamental biological process involving a conserved effector pathway.
  • This pathway is regulated by enzymes called caspases.
  • Proper regulation is crucial for preventing the accumulation of mutated cells.

Purpose of the Study:

  • To explore the regulation of apoptosis, particularly its connection to DNA damage.
  • To investigate the role of p53 and MSH-2 in this regulatory process.

Main Methods:

  • The study focuses on the structural changes and enzymatic pathways involved in apoptosis.
  • It examines the link between DNA damage and the apoptotic pathway.
  • It considers the implications of p53 and MSH-2 deficiencies in tumor development.

Related Experiment Videos

Main Results:

  • A conserved caspase-dependent pathway executes apoptosis, regardless of the initial trigger.
  • The coupling of DNA damage to apoptosis is critical for maintaining genomic stability.
  • Deficiencies in p53 or MSH-2 are frequently observed in tumors, suggesting their importance in this process.

Conclusions:

  • The regulation of the caspase pathway, especially its link to DNA damage, is vital for tumor suppression.
  • p53 and MSH-2 likely play key roles in connecting DNA damage signaling to apoptosis.