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Related Experiment Videos

Functionally adapted surfaces on a silicone keratoprosthesis.

S Langefeld1, N Völcker, S Kompa

  • 1Interdisciplinary Center for Clinical Research, Biomat, at the RWTH Aachen, Germany.

The International Journal of Artificial Organs
|August 31, 1999
PubMed
Summary
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Surface modification of silicone keratoprostheses enhances cell adhesion and tissue compatibility. Covalent binding of fibronectin to silicone surfaces improves cell proliferation, potentially reducing extrusion issues in implants.

Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Tissue Engineering

Background:

  • Silicone intraocular lenses, sponges, and bands are well-tolerated.
  • Current keratoprostheses face challenges with stability and extrusion.
  • Optimizing silicone surface properties is crucial for improved ocular implants.

Purpose of the Study:

  • To develop a novel one-piece silicone keratoprosthesis with enhanced cell adhesion.
  • To improve keratoprosthesis stability through surface modification.
  • To investigate methods for enhancing tissue compatibility of silicone surfaces.

Main Methods:

  • Tested various surface modifications on silicone foils.
  • Utilized cell cultures of murine and human conjunctival fibroblasts.

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  • Performed cytotoxicity assays and viability/morphology analyses.

    • Main Results:

    • No cytotoxicity observed for unmodified or modified silicone foils and extracts.
    • Improved cell morphology, spreading, and proliferation correlated with surface modification degree.
    • Covalent fibronectin immobilization yielded superior results compared to adsorptive binding.

    Conclusions:

    • Chemically modified silicone surfaces with bioactive proteins are cell-compatible and non-toxic.
    • Hydrophilization and protein immobilization enhance silicone biocompatibility and cell overgrowth.
    • Covalent fibronectin binding offers superior results, potentially reducing keratoprosthesis extrusion.