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Related Experiment Videos

Possible anaphylactic reaction to abciximab.

J A Guzzo1, T C Nichols

  • 1Department of Cardiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. jguzzo@email.unc.edu

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|August 31, 1999
PubMed
Summary
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A patient suffered a severe allergic reaction, including airway obstruction, after receiving abciximab during coronary stenting. Prompt treatment with epinephrine, steroids, and an H1 blocker successfully reversed the anaphylaxis.

Area of Science:

  • Cardiology
  • Anesthesiology
  • Pharmacology

Background:

  • Coronary artery stenting is a common procedure for treating coronary artery disease.
  • Abciximab is an antiplatelet medication frequently used during percutaneous coronary interventions.
  • Anaphylaxis is a rare but life-threatening systemic allergic reaction.

Observation:

  • A patient undergoing coronary artery stenting experienced a severe anaphylactic reaction shortly after abciximab administration.
  • The reaction manifested as profound hypotension and acute, severe airway obstruction.
  • The patient's condition required immediate and aggressive medical intervention.

Findings:

  • The anaphylactic reaction was directly linked to the administration of abciximab.
  • The patient's hypotension and airway compromise were critical signs of anaphylaxis.

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  • A combination of epinephrine, steroids, and an H1 blocker administered over 16 hours was effective in reversing the reaction.

    • Implications:

    • This case highlights the potential for severe anaphylactic reactions to abciximab during cardiac procedures.
    • Clinicians should be vigilant for anaphylaxis in patients receiving abciximab, especially those with pre-existing risk factors.
    • Rapid recognition and multi-agent treatment are crucial for managing abciximab-induced anaphylaxis effectively.