Related Experiment Video

Updated: Aug 19, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Assimilating new therapeutic interventions into clinical practice: how does hypertension compare with other

S G Carruthers1

  • 1London Health Sciences Centre and University of Western Ontario, London, Canada. medsgc@julian.uwo.ca

American Heart Journal
|September 1, 1999
PubMed

Insights

Despite proven cardiovascular disease therapies, inadequate clinical practice adoption leads to missed opportunities. Interventions are crucial to improve patient outcomes by promoting evidence-based treatment adherence.

Area of Science:

  • Cardiology
  • Health Services Research
  • Medical Education

Background:

  • Medical research identifies effective cardiovascular disease (CVD) therapies.
  • Inadequate adoption of these therapies into routine clinical practice is a significant issue.
  • This leads to suboptimal patient outcomes and missed opportunities to reduce CVD morbidity and mortality.

Purpose of the Study:

  • To review factors hindering the adoption of new medical practices.
  • To evaluate the effectiveness of interventions aimed at changing clinical behavior.
  • To identify strategies for improving the implementation of evidence-based cardiovascular treatments.

Main Methods:

  • Literature review of studies on clinical practice change and intervention effectiveness.
  • Analysis of barriers to adopting new therapeutic advances.
  • Synthesis of strategies for promoting adherence to proven treatments.

Main Results:

  • Numerous barriers impede the integration of new therapies into clinical practice.
  • The effectiveness of interventions designed to promote change varies considerably.
  • Suboptimal use of efficacious therapies results in benefits falling short of their potential.

Conclusions:

  • Improving the adoption of new cardiovascular therapies into clinical practice is essential.
  • Physicians need encouragement to prescribe proven treatments to eligible patients.
  • Enhanced systems of care are required for patient identification and long-term therapy adherence.

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.