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Determinants of pathogenicity of echovirus 9 in men: significance of a functional RGD-motif

B Nelsen-Salz1, O Schildgen, M Klein

  • 1Institut für Virologie der Universität zu Köln, Germany. birgit.nelsen-salz@medizin.uni-koeln.de

Zentralblatt Fur Bakteriologie : International Journal of Medical Microbiology
|September 1, 1999
PubMed

Insights

Echovirus 9 variants from children showed varying mouse pathogenicity, unrelated to human illness severity. All variants possess an RGD-motif, crucial but insufficient for mouse disease.

Area of Science:

  • Virology
  • Pathogen Discovery

Background:

  • Echovirus 9 is a significant human pathogen.
  • Understanding echovirus variant pathogenicity is crucial for public health.

Purpose of the Study:

  • To investigate the pathogenicity of nine independent echovirus 9 isolates in newborn mice.
  • To determine the correlation between human pathogenicity and mouse model pathogenicity for echovirus 9 variants.

Main Methods:

  • Isolation of nine echovirus 9 strains from human cases.
  • Assessment of pathogenicity in newborn mice.
  • Analysis of the VP1 protein for RGD-motif presence.

Main Results:

  • Significant variation in pathogenicity among echovirus 9 isolates in newborn mice.
  • No direct correlation observed between human disease severity and mouse pathogenicity.
  • All investigated echovirus 9 variants encode an RGD-motif in their VP1 protein.

Conclusions:

  • Mouse models may not accurately predict echovirus 9 human pathogenicity.
  • The RGD-motif in VP1 is a necessary but not sufficient factor for mouse pathogenicity in echovirus 9.

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