Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[In Process Citation]

Schindler

    Zentralblatt Fur Gynakologie
    |September 1, 1999
    PubMed
    Summary
    This summary is machine-generated.

    Aggressive treatment combining surgery and leuprorelin acetate for recurrent endometriosis significantly reduces disease severity and improves recurrence-free survival. This approach also enhances fertility outcomes and quality of life for affected patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    XXV Congress of the European Society of Neuroradiology and 9th Advanced Course

    Neuroradiology·2000
    Same author

    Metastructures: homeomorphisms between complex inorganic structures and three-dimensional nets.

    Acta crystallographica. Section B, Structural science·2000
    Same author

    Corrigendum to 'Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner'.

    Brain research. Developmental brain research·2000
    Same author

    Valence fluctuations and metallic behavior in K6Cu12U2S15, a new quaternary sulfide with a unique three-dimensional cubic framework

    Chemistry (Weinheim an der Bergstrasse, Germany)·2000
    Same author

    Mid-infrared quantum cascade lasers for flow injection analysis

    Analytical chemistry·2000
    Same author

    Data analysis of interaction forces measured with the atomic force microscope

    Ultramicroscopy·2000
    Same journal

    About 150 births naturally after previous Caesarean section.

    Zentralblatt fur Gynakologie·2010
    Same journal

    About lutein cysts found in hydrops foetus et placentae.

    Zentralblatt fur Gynakologie·2010
    Same journal

    The potencies of the burner epithelium, especially a tendency to form serous epitrel, squamous and mucosal epithelium.

    Zentralblatt fur Gynakologie·2010
    Same journal

    Two double birth defects causing obstetric difficulties.

    Zentralblatt fur Gynakologie·2010
    Same journal

    The uterine size and fundus level in the first part of pregnancy.

    Zentralblatt fur Gynakologie·2010
    Same journal

    The crossbar interposition.

    Zentralblatt fur Gynakologie·2010
    See all related articles

    Area of Science:

    • Gynecology
    • Reproductive Medicine
    • Surgical Oncology

    Background:

    • Recurrent endometriosis poses significant challenges, impacting fertility and quality of life.
    • Previous treatments often yield suboptimal outcomes, necessitating novel therapeutic strategies.

    Purpose of the Study:

    • To evaluate the efficacy of a "three-step" therapy for recurrent endometriosis.
    • To assess the impact of this combined approach on disease recurrence, fertility, and quality of life.

    Main Methods:

    • 112 patients with recurrent endometriosis underwent surgical removal of implants, followed by 6-month leuprorelin acetate depot injections.
    • A second-look laparoscopy was performed to assess residual disease.
    • Recurrence-free time and fertility outcomes were tracked for up to 60 months.

    Related Experiment Videos

    Main Results:

    • The combined "three-step" therapy reduced the revised American Fertility Society (r-AFS) score by 66%, compared to 34% with surgery alone.
    • Recurrence-free time was significantly correlated with the post-therapeutic r-AFS score; lower scores indicated longer remission.
    • 47.3% of infertile patients achieved pregnancy, with over 50% conceiving spontaneously.
    • Quality of life improved in 54.9% of patients.

    Conclusions:

    • A "three-step" therapy combining surgery and GnRH agonist treatment is highly effective in managing recurrent endometriosis.
    • Achieving a low post-therapeutic r-AFS score is crucial for preventing recurrence and preserving fertility.
    • Early, aggressive intervention is key to optimizing fertility outcomes in women with endometriosis.