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Related Experiment Videos

Training-induced brain plasticity in aphasia.

M Musso1, C Weiller, S Kiebel

  • 1Department of Neurology, Friedrich-Schiller-Universität Jena, Waldbreitbach, Germany. musso@neuro.uni-jena.de

Brain : a Journal of Neurology
|September 1, 1999
PubMed
Summary

This study on aphasia recovery found that intense language training led to improved verbal comprehension. Functional brain reorganization, particularly in the right hemisphere, supported this recovery in patients with Wernicke's aphasia.

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Aphasia recovery debate: left vs. right hemisphere involvement.
  • Wernicke's aphasia following left perisylvian lesions.
  • Understanding language network changes during recovery.

Purpose of the Study:

  • Investigate short-term cortical network changes in language comprehension during aphasia recovery.
  • Examine functional brain reorganization after targeted language training.
  • Identify brain regions associated with improved verbal comprehension.

Main Methods:

  • Positron Emission Tomography (PET) to measure regional cerebral blood flow (rCBF).
  • Four patients with Wernicke's aphasia underwent 12 rCBF measurements during a language comprehension task.

Related Experiment Videos

  • Modified Token Test assessed comprehension post-scan; intense training between scans.

    • Main Results:

    • All patients showed significant improvement in language comprehension.
    • Correlations revealed right superior temporal gyrus and left precuneus changes linked to comprehension gains.
    • Functional brain reorganization was associated with training-induced auditory comprehension improvement.

    Conclusions:

    • Supports a role for the right hemisphere in aphasia recovery.
    • Demonstrates functional brain reorganization underlies training-induced comprehension improvements.
    • Highlights the plasticity of language networks in aphasia recovery.