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Multiple primary melanoma.

N Conrad1, P Leis, I Orengo

  • 1Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|September 1, 1999
PubMed
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Individuals with atypical moles and a history of melanoma face a higher risk of cutaneous malignant melanoma (CMM). Early detection through regular total-body examinations is crucial for this high-risk group.

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Cutaneous malignant melanoma (CMM) incidence is rising globally in Caucasian populations.
  • Risk factors for CMM include a family history of melanoma and the presence of atypical moles.
  • Familial melanoma accounts for 6-12% of cases, with 12% of these patients developing multiple primary melanomas.

Observation:

  • This report details a case of a patient with numerous atypical moles and seventeen primary melanomas.
  • A literature review on multiple primary melanomas, their genetics, and treatment was conducted.

Findings:

  • Patients with numerous atypical moles and a personal or family history of melanoma are at the highest risk for CMM.
  • This high-risk group often develops CMM approximately a decade earlier than the general population.

Related Experiment Videos

  • Individuals in this cohort have a significantly increased risk of developing multiple primary melanomas.

    • Implications:

    • Currently, no genetic tests are available to identify inherited susceptibility to CMM.
    • Close monitoring with regular total-body examinations is essential for identifying at-risk individuals.
    • Early identification and surveillance are critical for managing CMM in high-risk populations.