A study of cutaneous tuberculosis in children
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Published on: August 11, 2018
V Ramesh1, R S Misra, K R Beena
1Department of Dermatology and Venereology and Institute of Pathology (ICMR), Safdarjang Hospital, New Delhi, India.
Insights
Cutaneous tuberculosis in children, primarily lupus vulgaris and scrofuloderma, presents unique challenges. Early diagnosis and consistent treatment are crucial to prevent severe complications and disfigurement.
Area of Science:
- Dermatology
- Infectious Diseases
- Pediatrics
Background:
- Cutaneous tuberculosis (TB) is a significant global health issue, particularly in children.
- Diagnosis can be challenging due to low culture positivity rates.
- Understanding pediatric cutaneous TB manifestations is vital for effective management.
Purpose of the Study:
- To analyze the clinical presentation and outcomes of cutaneous tuberculosis in children.
- To identify challenges in diagnosis and management.
- To compare pediatric presentations with adult cutaneous TB.
Main Methods:
- Retrospective study of 199 patients with cutaneous TB over 7 years.
- Inclusion of 63 pediatric patients.
- Diagnosis based on clinical examination, tuberculin reaction, histopathology, and treatment response.
Main Results:
- Lupus vulgaris (LV) affected 40 children, predominantly the lower body with hypertrophic/keratotic forms; scrofuloderma (SD) affected 23, often involving cervical lymph nodes.
- Regional lymph node involvement was more common in pediatric LV than in adults.
- Co-occurrence of LV and SD was less frequent in children.
Conclusions:
- Pediatric cutaneous TB, particularly LV and SD, requires prompt diagnosis and management.
- Challenges include late diagnosis, irregular therapy, and lack of awareness.
- Improved practitioner awareness and community support are needed to mitigate complications.
Abstract:
Sixty-three children out of a total of 199 patients seen with cutaneous tuberculosis during a 7-year period were included in this study. Culture was positive in only four, and the diagnosis was based on clinical examination, tuberculin reaction, histopathology, and response to antitubercular therapy. Forty had lupus vulgaris (LV) and 23 scrofuloderma (SD). The lower half of the body was predominantly affected in those with LV, and keratotic and hypertrophic forms were frequently encountered. LV planus mainly affected the face. Ulcerative and atrophic types of LV were infrequent. Extensive lesions in three children led to disfiguring scars and contractures. Scrofuloderma often involved the cervical group of lymph nodes followed by the inguinal, submandibular, and axillary groups. As compared to skin tuberculosis in adults, regional lymph node involvement in LV was more common, and a combination of both LV and SD was less frequent in children. No difference in clinical presentation could be detected between the BCG vaccinated and unvaccinated children. Tuberculous infection either in the lungs or the bones was present in eight children. An HIV test done in five patients with widespread lesions was negative. Irregular therapy or late diagnosis leading to serious complications, inadequate parental or community support, and lack of awareness among practitioners are the problems to be remedied.
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