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Related Experiment Videos

Calcipotriol in vitiligo: a preliminary study.

D Parsad1, R Saini, R Nagpal

  • 1Department of Dermatology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India. dprsaini@nde.vsnl.net.in

Pediatric Dermatology
|September 1, 1999
PubMed
Summary

Topical calcipotriol shows promise for treating childhood vitiligo. This study found that calcipotriol treatment led to significant repigmentation in most pediatric patients with vitiligo, with good cosmetic outcomes and minimal side effects.

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Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Phototherapy

Background:

  • Vitiligo is a chronic pigmentation disorder affecting children.
  • Psoralens remain the primary treatment for vitiligo.
  • Recent molecular insights into vitiligo pathogenesis and observed hyperpigmentation with calcipotriol in psoriasis patients informed this study.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical calcipotriol as a novel treatment for vitiligo in children.
  • To assess repigmentation rates and cosmetic outcomes in pediatric vitiligo patients using calcipotriol therapy.

Main Methods:

  • A study involving 21 pediatric patients (ages 5-17) with vitiligo.
  • Patients applied calcipotriol 50 microg/g in the evening, followed by 10-15 minutes of sunlight exposure the next day.

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  • Follow-up assessments occurred at 3-week intervals to monitor repigmentation and side effects.

    • Main Results:

    • Initial repigmentation was observed in the majority of children within 6-12 weeks.
    • Marked to complete repigmentation occurred in 10 out of 18 patients; 4 showed moderate improvement, and 4 had minimal/no improvement.
    • No new lesions developed, and repigmentation was cosmetically excellent in most patients. Three patients reported mild irritation; serum calcium levels remained normal.

    Conclusions:

    • Topical calcipotriol is a potentially effective and safe treatment for childhood vitiligo, offering encouraging repigmentation with good cosmetic results.
    • This treatment represents a promising alternative for pediatric vitiligo management, warranting further investigation.