Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Giant proteases: beyond the proteasome.

T Yao1, R E Cohen

  • 1Department of Biochemistry, University of Iowa, Bowen Science Building, 51 Newton Road, Iowa City, Iowa 52242-1109, USA.

Current Biology : CB
|September 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of thermally driven quasi-1D superionic states in carbon hydride under giant planetary conditions.

Nature communications·2026
Same author

Absence of High-Pressure Ground-State Reentrant Ferroelectricity in PbTiO_{3}.

Physical review letters·2024
Same author

Computational Screening and Stabilization of Boron-Substituted Type-I and Type-II Carbon Clathrates.

Journal of the American Chemical Society·2023
Same author

Ultrahigh-pressure disordered eight-coordinated phase of Mg<sub>2</sub>GeO<sub>4</sub>: Analogue for super-Earth mantles.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Measuring the melting curve of iron at super-Earth core conditions.

Science (New York, N.Y.)·2022
Same author

Thermal conductivity of Fe-Si alloys and thermal stratification in Earth's core.

Proceedings of the National Academy of Sciences of the United States of America·2021

Giant proteases, a newly discovered class of enzymes, can enhance or even replace proteasomes for intracellular protein breakdown. This finding expands our understanding of cellular catabolism and protein homeostasis.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Proteasomes are the primary known machinery for intracellular protein degradation.
  • Understanding protein turnover is crucial for cellular health and disease.

Purpose of the Study:

  • To report the discovery of a new class of proteases.
  • To investigate the role of these novel proteases in cellular protein degradation.

Main Methods:

  • Characterization of novel protease activity.
  • Assays for protein degradation in cellular models.

Main Results:

  • A new class of giant proteases has been identified.
  • These proteases can supplement proteasome function.

Related Experiment Videos

  • Under certain conditions, they may substitute for proteasomes.

    • Conclusions:

    • Giant proteases represent a significant addition to the known protein degradation machinery.
    • These enzymes have the potential to play a major role in cellular catabolism.