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Related Experiment Videos

Chromosomal location effects on gene sequence evolution in mammals.

G Matassi1, P M Sharp, C Gautier

  • 1Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK. gmatassi@infobiogen.fr

Current Biology : CB
|September 2, 1999
PubMed
Summary

Mammalian gene evolution shows regional differences. Neighboring genes exhibit similar substitution rates and G+C content, suggesting distinct chromosomal regions evolve at varied rates.

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Genetics

Background:

  • Mammalian genomes exhibit significant variation in nucleotide substitution rates and guanine-cytosine (G+C) content among genes.
  • The mammalian genome is hypothesized to be a mosaic of isochores with differing G+C content.
  • Factors influencing regional variation in nucleotide substitution rates remain largely unexplored.

Purpose of the Study:

  • To investigate the influence of chromosomal location on nucleotide substitution rates and gene G+C content in mammals.
  • To determine if regional similarities in G+C content correlate with substitution rate variations.

Main Methods:

  • Comparison of human and murid orthologous genes within conserved chromosomal segments.
  • Analysis of synonymous substitution rates and G+C content at silent sites.

Related Experiment Videos

  • Definition and analysis of neighboring genes within 1 centiMorgan (cM) on the mouse genetic map.

    • Main Results:

    • Neighboring genes demonstrated significantly higher similarity in both synonymous substitution rates and G+C content compared to randomly selected gene sets.
    • Regional similarities in G+C content (isochores) and synonymous substitution rate were found to be independent.
    • Statistical evidence supports regional variation in synonymous substitution rates within the mammalian genome.

    Conclusions:

    • The study provides robust statistical evidence for regional variation in synonymous substitution rates across the mammalian genome.
    • Different chromosomal regions evolve at distinct rates, impacting gene evolution.
    • These findings suggest the existence of 'evolutionary rate units' along mammalian chromosomes.