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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
Yersinia enterocolitis mimicking Crohn's disease in a toddler
A M Tuohy1, M O'Gorman, C Byington
1Department of, University of Utah School of Medicine, Primary Children's Medical Center, Salt Lake City, Utah 84113-1100, USA.
Insights
Pediatric Yersinia enterocolitis can mimic Crohn's disease, presenting with severe gastrointestinal symptoms and inflammation. Prompt identification and antibiotic treatment are crucial for recovery.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Yersinia enterocolitica infection can present with diverse clinical manifestations in children.
- Distinguishing infectious colitis from inflammatory bowel disease is a diagnostic challenge.
Observation:
- A 3.5-year-old girl exhibited symptoms of persistent abdominal pain, fever, vomiting, diarrhea, rash, oral ulceration, and anemia.
- Imaging revealed ileocecal edema and mesenteric adenopathy; colonoscopy showed colitis, and enteroclysis demonstrated terminal ileum inflammation.
Findings:
- Initial diagnosis considered Crohn's disease due to clinical deterioration despite antibiotics.
- Yersinia enterocolitica was identified on hospital day nine, leading to trimethoprim/sulfamethoxazole treatment.
- The patient showed prompt clinical improvement after initiating appropriate antibiotic therapy.
Implications:
- This case highlights the importance of considering infectious etiologies, such as Yersinia enterocolitis, in pediatric patients with suspected inflammatory bowel disease.
- The comprehensive clinical description provides valuable insights into the diagnostic challenges and presentation of Yersinia enterocolitis in children.
- Early and accurate diagnosis of Yersinia enterocolitis can prevent unnecessary immunosuppressive therapy and guide appropriate antimicrobial treatment.
Abstract:
A 31/2-year-old girl presented with persistent abdominal pain, fever, vomiting, and diarrhea accompanied by rash, oral ulceration, anemia, and an elevated sedimentation rate. Initial evaluation revealed no pathogens and was extended to include abdominal ultrasound and computed tomography showing marked ileocecal edema and mesenteric adenopathy. Colonoscopy revealed focal ulceration from rectum to cecum with histology of severe active colitis with mild chronic changes. Enteroclysis demonstrated a nodular, edematous terminal ileum. Because of the patient's clinical deterioration despite antibiotics, these features were construed consistent with Crohn's disease, and glucocorticoid therapy was begun. By the ninth hospital day, admission cultures grew Yersinia enterocolitica, and trimethoprim/sulfamethoxazole was begun followed by prompt clinical improvement. The delay in diagnosis afforded an unusually comprehensive clinical description of the presentation and diagnosis of Yersinia enterocolitis in childhood.
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