Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Idiopathic nodular glomerulosclerosis.

A M Herzenberg1, J K Holden, S Singh

  • 1Department of Medicine, St. Paul's Hospital, Vancouver, BC, Canada.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|September 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurosensory assessments of migraine.

Brain research·2013
Same author

Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
Same author

Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.

Diabetologia·2012
Same author

Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake.

Diabetologia·2012
Same author

Our approach to a renal transplant biopsy.

Journal of clinical pathology·2009
Same author

Renal toxicity of therapeutic drugs.

Journal of clinical pathology·2009

Idiopathic nodular glomerulosclerosis, a rare kidney disease, presents like diabetic glomerulosclerosis but without diabetes. Research suggests arteriolar stenosis and glomerular ischemia may cause these lesions.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Idiopathic nodular glomerulosclerosis (ING) shares histological features with diabetic nodular glomerulosclerosis.
  • Distinguishing ING from diabetic kidney disease is crucial for accurate diagnosis and management.

Observation:

  • Two patients presented with ING, characterized by nodular glomerulosclerosis, arteriolosclerosis, thickened glomerular basement membranes, mesangiolysis, and capillary microaneurysms.
  • Neither patient exhibited abnormal glucose metabolism or other diabetic mellitus indicators.

Findings:

  • Literature review revealed 27 previously reported ING cases; 11 had abnormal glucose metabolism or diabetes.
  • Of the 16 cases with normal glucose, 3 had diabetic retinopathy and 1 had impaired insulin response.

Implications:

Related Experiment Videos

  • The findings highlight the importance of excluding diabetes in cases of nodular glomerulosclerosis.
  • Arteriolar stenosis and resultant glomerular ischemia are proposed as potential pathogenetic mechanisms for ING.