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Occupation and histopathology of lung cancer: A case-control study in Rosario, Argentina
1Institute of Immunology, School of Medicine, National University of Rosario, Argentina. smpezzotto@mailcity.com
Background:
Male age-adjusted lung cancer mortality rate is high in Rosario City, Argentina (62.7 per 100,000).
Methods:
Case-control study involving interviews with 367 male lung cancer patients and 576 controls.
Results:
The histological distribution detected was: squamous cell 39%, adenocarcinoma 34%, small cell carcinoma 13%, and other or no specified cell type 14%. When comparing with the group unlikely to be exposed to occupational carcinogens, a 60% increase in risk was observed for the remaining occupations (P < 0.008). Risks were high for drivers (OR=1.9, CI: 1.1-4.0), construction (OR=2.5, CI: 1.0-5.9), and agricultural workers also (OR=1.8, CI: 1. 1-3.1). In regard to squamous cell carcinoma, increased risks were observed in the metal industry, particularly in welders (OR=2.9, CI: 1.0-10.1) and mechanics (OR=1.8, CI: 0.9-4.2). Smoking was not a substantial confounding effect.
Conclusions:
Occupational exposures partly account for the high lung cancer mortality rate among male residents of Rosario City.