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Related Experiment Videos

Selective serotonin-reuptake inhibitors: an update.

P S Masand1, S Gupta

  • 1Psychiatric Consultation Service, Regional Psychopharmacology Consultation and Training Program, SUNY Health Science Center at Syracuse, NY 13210, USA.

Harvard Review of Psychiatry
|September 2, 1999
PubMed
Summary

Selective serotonin-reuptake inhibitors (SSRIs) are effective treatments for various mood disorders due to their safety and tolerability. This review highlights their broad therapeutic applications and potential side effects.

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Neuroscience

Background:

  • Selective serotonin-reuptake inhibitors (SSRIs) are a distinct class of antidepressants.
  • They are chemically unrelated to older antidepressant generations like tricyclics.
  • SSRIs offer advantages in efficacy, safety, and patient compliance.

Purpose of the Study:

  • To review the current literature on SSRIs.
  • To identify the therapeutic indications for SSRIs.
  • To summarize the side effect profile of SSRIs.

Main Methods:

  • A literature review was performed using Medline.
  • Search terms included "SSRIs," "fluoxetine," "sertraline," "paroxetine," "fluvoxamine," and "citalopram."
  • Articles were limited to English language publications within the last 15 years.

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Main Results:

  • SSRIs are indicated for major depression, dysthymia, panic disorder, obsessive-compulsive disorder, eating disorders, and premenstrual dysphoric disorder.
  • Fluoxetine has shown safety during pregnancy.
  • Common side effects include gastrointestinal issues, headache, sedation, insomnia, and sexual dysfunction.

Conclusions:

  • SSRIs are a preferred pharmacotherapy for numerous mood and anxiety disorders.
  • Their favorable side-effect profile and safety contribute to their widespread use.
  • Understanding SSRI indications and side effects is crucial for effective treatment.