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Tomato consumption modulates oxidative DNA damage in humans.

A Rehman1, L C Bourne, B Halliwell

  • 1International Antioxidant Research Centre, Guy's, King's and St Thomas's School of Biomedical Sciences, Guy's Campus, London Bridge, London, SE1 9RT, United Kingdom.

Biochemical and Biophysical Research Communications
|September 2, 1999
PubMed
Summary

Consuming tomatoes reduced harmful 8-hydroxyguanine DNA damage in healthy adults within 24 hours. This dietary effect on oxidative DNA damage may explain how fruits and vegetables help lower cancer risk.

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Area of Science:

  • Nutritional Science
  • Molecular Biology
  • Genetics

Background:

  • Oxidative DNA damage is implicated in aging and diseases like cancer.
  • Dietary factors, particularly antioxidants from fruits and vegetables, are thought to mitigate this damage.
  • Understanding the short-term effects of specific foods is crucial for dietary recommendations.

Purpose of the Study:

  • To investigate the immediate impact of tomato consumption on oxidative DNA base damage in humans.
  • To identify specific DNA damage markers affected by dietary intake of tomatoes.

Main Methods:

  • Healthy volunteers consumed a single serving of tomatoes.
  • Levels of oxidative DNA base damage, including 8-hydroxyguanine and 8-hydroxyadenine, were measured in white blood cell DNA before and after consumption.

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  • Changes were analyzed within 24 hours.

    • Main Results:

    • A single tomato serving significantly altered oxidative DNA base damage levels within 24 hours.
    • Levels of the mutagenic 8-hydroxyguanine decreased, particularly in subjects with initially higher levels.
    • Total DNA base damage remained unchanged due to a concurrent rise in 8-hydroxyadenine levels.

    Conclusions:

    • Short-term tomato consumption can modulate specific markers of oxidative DNA damage.
    • The observed changes suggest a potential mechanism linking dietary intake of tomatoes to reduced cancer incidence.
    • Further research into the long-term effects and specific compounds in tomatoes is warranted.