Related Experiment Video

Updated: Aug 7, 2026

EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay
11:09

EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay

Published on: September 11, 2016

Activity of pleconaril against enteroviruses

D C Pevear1, T M Tull, M E Seipel

  • 1ViroPharma Incorporated, Exton, Pennsylvania 19341, USA. dpevear@viropharma.com

Antimicrobial Agents and Chemotherapy
|September 3, 1999
PubMed

Insights

Pleconaril effectively inhibited enterovirus replication in cell cultures and improved survival rates in animal models. This antiviral drug shows promise for treating human enteroviral infections.

Area of Science:

  • Virology
  • Pharmacology
  • Infectious Diseases

Background:

  • Enteroviruses cause significant human illness.
  • Limited effective antiviral treatments exist for enteroviral infections.

Purpose of the Study:

  • To evaluate the antiviral activity of pleconaril against clinical enterovirus isolates.
  • To assess the efficacy of pleconaril in animal models of enteroviral infection.

Main Methods:

  • Cell culture assays were used to determine pleconaril's inhibitory concentration against enterovirus serotypes.
  • Animal models (mice) were used to test pleconaril's oral efficacy in prophylactic and therapeutic settings.

Main Results:

  • Pleconaril inhibited 50% of clinical enterovirus isolates at <=0.03 microM and 90% at <=0.18 microM.
  • Echovirus serotype 11, a prevalent serotype, was highly sensitive to pleconaril.
  • Pleconaril treatment increased survival rates in three lethal enterovirus infection models and reduced viral load in tissues.

Conclusions:

  • Pleconaril demonstrates potent in vitro and in vivo antiviral activity against a broad range of enteroviruses.
  • Pleconaril is a promising drug candidate for the treatment of human enteroviral infections.

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