Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteoinductive bone graft substitutes for spinal fusion: a basic science summary.

S C Ludwig1, S D Boden

  • 1Department of Orthopaedic Surgery, The Emory Spine Center, Emory University School of Medicine, Atlanta, Georgia, USA.

The Orthopedic Clinics of North America
|September 3, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AOA Critical Issues Symposium: So, You Want to Be a Department Leader: Essentials for Success.

The Journal of bone and joint surgery. American volume·2024
Same author

Experimentally elevated levels of testosterone at independence reduce fitness in a territorial bird.

Ecology·2014
Same author

Condition- and parasite-dependent expression of a male-like trait in a female bird.

Biology letters·2011
Same author

Spine fusion by gene therapy.

Gene therapy·2004
Same author

Demineralized bone matrix, bone morphogenetic proteins, and animal models of spine fusion: an overview.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2001
Same author

Do the intervertebral disc cells respond to different levels of hydrostatic pressure?

Clinical biomechanics (Bristol, Avon)·2001

Spinal fusion healing is complex, involving multiple biologic mechanisms. Advances in animal models and gene therapy are paving the way for new biologic manipulation techniques in spinal fusion.

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Spinal fusion healing is a complex biological process.
  • Current understanding of its molecular mechanisms is evolving.
  • Traditional fusion methods have limitations.

Purpose of the Study:

  • To review the current understanding of spinal fusion biology.
  • To highlight advancements in animal models for studying spinal fusion.
  • To discuss emerging biologic therapies for enhancing spinal fusion.

Main Methods:

  • Review of current molecular biology research on spinal fusion.
  • Analysis of advancements in animal models for arthrodesis.
  • Evaluation of new therapeutic approaches like gene therapy and osteoinductive factors.

Related Experiment Videos

Main Results:

  • Spinal fusion is a multifactorial and complex process.
  • Improved animal models have significantly advanced basic science knowledge.
  • Gene therapy, osteoinductive proteins, and carrier matrices show promise.

Conclusions:

  • Understanding of spinal fusion biology is rapidly advancing.
  • New biologic manipulation strategies are emerging for orthopedic surgeons.
  • Future treatments will likely involve targeted biologic interventions for fusion.