Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in early prostatic cancer.

V G Gorgoulis1, D G Tiniakos, G Mariatos

  • 1Department of Histology and Embryology, School of Medicine, University of Athens, Greece.

Anticancer Research
|September 3, 1999
PubMed
Summary

Early prostate cancer detection is improving with advanced diagnostics like PSA tests and ultrasounds. Further research into molecular markers aids in understanding tumor progression and optimizing patient treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stillbirth due to SARS-CoV-2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk factors.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
Same author

Correction to: Keratin 7 expression in hepatic cholestatic diseases.

Virchows Archiv : an international journal of pathology·2021
Same author

Keratin 7 expression in hepatic cholestatic diseases.

Virchows Archiv : an international journal of pathology·2021
Same author

Simulation of schoolyard's microclimate and human thermal comfort under Mediterranean climate conditions: effects of trees and green structures.

International journal of biometeorology·2018
Same author

Microclimatic effects of planted hydroponic structures in urban environment: measurements and simulations.

International journal of biometeorology·2016
Same author

Validation and development of MTH1 inhibitors for treatment of cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2016

Area of Science:

  • Oncology
  • Urology
  • Molecular Biology

Background:

  • Early prostatic carcinoma is a localized, slow-growing malignancy.
  • Improved diagnostic methods have increased the detection frequency of early prostate cancer.

Purpose of the Study:

  • To review current diagnostic and prognostic markers for early prostate cancer.
  • To highlight the role of emerging molecular and cytogenetic techniques in understanding prostate cancer progression.
  • To emphasize the ultimate goal of improving patient therapeutic management.

Main Methods:

  • Combination of digital rectal examination, serum PSA levels, and transrectal ultrasound for diagnosis.
  • Core needle biopsy and immunohistochemistry (clone 34 beta E12) for suspected cases.
  • Cytogenetic and molecular biological methods for investigating localized prostate carcinomas.

Related Experiment Videos

Main Results:

  • The combination of DRE, PSA, and TRUS is the current gold standard for diagnosis.
  • Immunohistochemistry with clone 34 beta E12 is valuable for early, low-grade tumors.
  • Molecular and cytogenetic analyses are crucial for identifying progression markers.

Conclusions:

  • Accurate diagnosis and staging of early prostate cancer rely on integrated clinical and pathological assessments.
  • Investigating molecular alterations is key to understanding carcinogenesis and tumor progression.
  • The ultimate aim is to leverage all diagnostic and prognostic information for optimal patient treatment.