Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anti-infective aerosols].

P Diot1, P F Dequin, B Rivoire

  • 1Service de pneumologie et d'explorations fonctionnelles respiratoires, UPRES-EA 2638, Tours.

Revue Des Maladies Respiratoires
|September 3, 1999
PubMed
Summary

Aerosol delivery of anti-infective drugs like colistin is an emerging empirical approach. Research shows nebulization processes, including ultrasound, do not degrade drug efficacy, supporting this method for infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea: Update on French practices and position paper of the SFRMS, SPLF and SFORL sleep medicine work-group.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

Job-exposure matrix (JEM) validity on crystalline silica among systemic sclerosis patients.

Occupational medicine (Oxford, England)·2025
Same author

Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study.

Seminars in arthritis and rheumatism·2024
Same author

The genus <i>Fomitopsis</i> (<i>Polyporales</i>, <i>Basidiomycota</i>) reconsidered.

Studies in mycology·2024
Same author

Corrigendum to 'Management of obstructive sleep apnea syndrome type 1 in children and adolescents - A French consensus' [Arch Pediatr (2023) 510-16].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2024
Same author

Management of obstructive sleep apnea syndrome type 1 in children and adolescents - A French consensus.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2023

Area of Science:

  • Pharmacology
  • Drug Delivery
  • Infectious Diseases

Context:

  • Aerosol administration of anti-infective agents is an unapproved empirical method.
  • Nebulization's impact on drug integrity is a key concern for aerosolized antibiotics and antifungals.

Purpose:

  • To evaluate the stability of anti-infective drugs during nebulization.
  • To assess the influence of nebulizer type and characteristics on aerosol generation and drug delivery.
  • To explore novel pharmacological monitoring for aerosolized anti-infective treatments.

Summary:

  • High-frequency ultrasound does not degrade colistin, a polypeptide antibiotic, indicating stability for other sensitive molecules like aminoglycosides.
  • Both ultrasonic and jet nebulizers can aerosolize amphotericin B and colistin; device performance, not nebulization method, determines effectiveness.

Related Experiment Videos

  • Effective aerosol therapy requires a high inhaled mass in the respirable range, with dosimetric nebulizers offering significant advancements.

    • Impact:

    • Findings support the viability of aerosolized anti-infectives, particularly for respiratory tract infections.
    • This research encourages further development and official approval of aerosolized drug delivery systems.
    • Urinary assays show promise for monitoring treatment efficacy in patients receiving aerosolized anti-infectives.