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[Paraneoplastic hypercorticism associated with a bronchial adenocarcinoma]
R Schott1, A Chaouat, M Tavernier
1Service de Pneumologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg.
Revue Des Maladies Respiratoires
|September 3, 1999
Summary
Lung adenocarcinoma can cause Cushing's syndrome, presenting unique clinical and biological features distinct from classical Cushing's disease. Ketoconazole offers symptomatic relief when primary treatment is ineffective.
Area of Science:
- Endocrinology
- Oncology
Background:
- Cushing's syndrome is rare in lung adenocarcinoma patients.
- Ectopic adrenocorticotropic hormone (ACTH) production can cause Cushing's syndrome.
Observation:
- A case report details a patient with lung adenocarcinoma presenting with Cushing's syndrome.
- Clinical and biological features differed from typical Cushing's disease.
- Symptoms included unique signs and suggestive biological markers.
Findings:
- The specific pathogenesis of lung adenocarcinoma-associated Cushing's syndrome explains the observed clinical and biological variations.
- Ketoconazole demonstrated efficacy in managing both clinical signs and biological abnormalities.
Implications:
- Highlights the importance of considering ectopic ACTH syndrome in lung cancer patients with Cushingoid features.
- Suggests ketoconazole as a potential therapeutic option for managing symptoms when etiological treatment is insufficient.
- Underscores the distinct pathophysiology of Cushing's syndrome secondary to lung adenocarcinoma.